NU-6027
CAS No. 220036-08-8
NU-6027( NU6027 | NU 6027 )
Catalog No. M13509 CAS No. 220036-08-8
NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 183 | In Stock |
|
| 100MG | 272 | In Stock |
|
| 200MG | 393 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNU-6027
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NoteResearch use only, not for human use.
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Brief DescriptionNU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
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DescriptionNU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively; inhibits human tumor cells with a mean GI50 of 10 ±6 uM; also inhibits cellular ATR (IC50=6.7 uM) and RAD51 focus formation, increases the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy.
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In VitroNU6027 (1 nM-100 μM; 48 h) inhibits the growth of human tumor cells with a GI50 of 10±6 μM.NU6027 (0.1-25 μM; 24 h) inhibits ATR activity with an IC50 of 2.8 μM in GM847KD cells. NU6027 (1-10 μM; 24 h) inhibits ATR activity with an IC50 of 6.7±2.3 μM in MCF7 cells.NU6027 (4 or 10 μM; 24 h) attenuates G2/M arrest following DNA damage in MCF7 cells.NU6027 (10 μM; 24 h) significantly reduces RAD51 foci in both control and PF-01367338-treated V-C8 B2 cells.NU6027 (4 μM; 24 h) causes 82% suppression of the increase in RAD51 foci-positive cells treated by PF-01367338.Western Blot Analysis Cell Line:MCF7 cells Concentration:0, 1, 5, 10 μM Incubation Time:24 h Result:Inhibited CDK2-mediated pRbT821 by 42±27% compared with 70±12% inhibition of pCHK1S345 with the concentration of 10 μM.
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In Vivo——
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SynonymsNU6027 | NU 6027
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PathwayAngiogenesis
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TargetCDK
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RecptorATR|CDK1|CDK2|DNA-PK
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number220036-08-8
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Formula Weight251.3
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Molecular FormulaC11H17N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 47 mg/mL (187 mM); Ethanol: 3 mg/mL (11.93 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESNC1=NC(OCC2CCCCC2)=C(N=O)C(N)=N1
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Chemical Name6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.
2. Peasland A, et al. Br J Cancer. 2011 Jul 26;105(3):372-81.
3. Boschi D, et al. Eur J Med Chem. 2013 Oct;68:333-8.
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