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SR10067

CAS No. 1380548-02-6

SR10067( —— )

Catalog No. M26464 CAS No. 1380548-02-6

SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SR10067
  • Note
    Research use only, not for human use.
  • Brief Description
    SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.
  • Description
    SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.
  • In Vitro
    SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively.
  • In Vivo
    SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse. Animal Model:Mice Dosage:30 mg/kg Administration:i.p.Result:Remained above the IC50 of the receptor in plasma and brain concentrations. Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1380548-02-6
  • Formula Weight
    465.593
  • Molecular Formula
    C31H31NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (214.79 mM)
  • SMILES
    CC(C)(C)Oc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gupta BS, Taha M, Lee MJ. Buffers more than buffering agent: introducing a new class of stabilizers for the protein BSA. Phys Chem Chem Phys. 2015 Jan 14;17(2):1114-33.
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