Cart
sales@molnova.com
SR-318
CAS No. 2413286-32-3
SR-318( —— )
Catalog No. M26463 CAS No. 2413286-32-3
SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
|
| 2MG | 30 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 84 | In Stock |
|
| 25MG | 169 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 384 | In Stock |
|
| 200MG | 551 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSR-318
-
NoteResearch use only, not for human use.
-
Brief DescriptionSR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
-
DescriptionSR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.(In Vitro):SR-318 shows anti-cancer and anti-inflammatory activity. SR-318 can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms, p38α/β.
-
In VitroSR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2413286-32-3
-
Formula Weight459.58
-
Molecular FormulaC27H33N5O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (271.99 mM)
-
SMILESNc(n(-c1ccccc1)nc1)c1C(NCc(cc1)ccc1C(NCCCC1CCCCC1)=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review.
molnova catalog
related products
-
PAF (C16)
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
-
Epicatechin
(-)-Epicatechin is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
-
VX-702
A potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.
