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SIRT-IN-1
CAS No. 1431411-60-7
SIRT-IN-1( —— )
Catalog No. M26447 CAS No. 1431411-60-7
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 5MG | 178 | In Stock |
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| 10MG | 296 | In Stock |
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| 25MG | 504 | In Stock |
|
| 50MG | 697 | In Stock |
|
| 100MG | 986 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSIRT-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionSIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
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DescriptionSIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).(In Vitro):SIRT-IN-1 is one of the most potent inhibitor of truncated pan SIRT1/ 2/3(IC50 values are 0.015, 0.010, 0.033 μM, respectively). SIRT-IN-1 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
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In VitroSIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorKRas G12C
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Research Area——
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Indication——
Chemical Information
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CAS Number1431411-60-7
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Formula Weight389.52
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Molecular FormulaC19H27N5O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 19.23 mg/mL (49.37 mM)
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SMILESCC(C)(C)C(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.
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