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Sigma-1 receptor antagonist 1

CAS No. 1639220-19-1

Sigma-1 receptor antagonist 1( —— )

Catalog No. M26443 CAS No. 1639220-19-1

Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Sigma-1 receptor antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.
  • Description
    Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.(In Vitro):Sigma 1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold).(In Vivo):In mice formalin model and rats CCI models of neuropathic pain, Sigma 1 receptor antagonist 1 exerts dose-dependent antinociceptive effects.
  • In Vitro
    Sigma?1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki = 1.06 nM) and good σ-1/2 selectivity (1344-fold).
  • In Vivo
    Sigma1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Sigma receptor
  • Recptor
    TLR7| TLR8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1639220-19-1
  • Formula Weight
    380.31
  • Molecular Formula
    C19H23Cl2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.25 mg/mL (16.43 mM)
  • SMILES
    Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Martha A. MILLER, et al. Vaccine compositions and methods of use to treat neonatal subjects.
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