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Home - Products - Metabolic Enzyme/Protease - Phosphatase - SHIP2-IN-1

SHIP2-IN-1

CAS No. 2252247-80-4

SHIP2-IN-1( —— )

Catalog No. M26440 CAS No. 2252247-80-4

SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 μM),and used in the research of Alzheimer’s disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SHIP2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 μM),and used in the research of Alzheimer’s disease.
  • Description
    SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 μM),and used in the research of Alzheimer’s disease.(In Vitro):PI(3,4)P2 production in HT22 cellssignificantly inhibited by SHIP2-IN-1 (10 μM) .
  • In Vitro
    SHIP2-IN-1 (Compound 43; 10 μM) significantly inhibits PI(3,4)P2 production in HT22 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    α4β1δ GABAA receptor| α4β3δ GABAA receptor| αβγ GABAA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2252247-80-4
  • Formula Weight
    379.22
  • Molecular Formula
    C17H13Cl2FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (263.70 mM)
  • SMILES
    C[C@@H](Oc1cncc(c1)-c1cnc(N)nc1)c1c(Cl)ccc(F)c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.
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