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SGC-iMLLT
CAS No. 2255338-25-9
SGC-iMLLT( —— )
Catalog No. M26437 CAS No. 2255338-25-9
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 44 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSGC-iMLLT
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NoteResearch use only, not for human use.
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Brief DescriptionSGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
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DescriptionSGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).(In Vivo):After 60 min, SGC-iMLLT shows moderate metabolic resistance (t1/2 53 min, 48 % remaining), with a primary process for metabolism being N demethylation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number2255338-25-9
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Formula Weight388.475
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Molecular FormulaC22H24N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (214.51 mM)
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SMILESC[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4n(C)ncc4c3)ccc2[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Christoffersson E, Edlund Y, Gamklou R, Nilsson LA. Microbiological activity of sulfaproxyline-sulfamerazine in gallbladder bile from patients with gallstone disease. Scand J Clin Lab Invest. 1966;18(2):254-60.
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