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OMDM-1
CAS No. 616884-62-9
OMDM-1( (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide )
Catalog No. M26347 CAS No. 616884-62-9
OMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 410 | Get Quote |
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| 10MG | 601 | Get Quote |
|
| 25MG | 954 | Get Quote |
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| 50MG | 1278 | Get Quote |
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| 100MG | 1728 | Get Quote |
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| 500MG | 3465 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameOMDM-1
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NoteResearch use only, not for human use.
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Brief DescriptionOMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.
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DescriptionOMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.(In Vitro):OMDM-1 is anovel potent and selective inhibitors of ACU and one "hybrid" agonist of CB(1) and VR1 receptors (OMDM-6). Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.The (R)- and, particularly, the (S)-1'-(4-hydroxybenzyl) derivatives of N-oleoylethanolamine and AEA (OMDM-1, OMDM-2, OMDM-3, and OMDM-4) inhibited to a varied extent ACU in RBL-2H3 cells (K(i) ranging between 2.4 and 17.7 micro M), the oleoyl analogues (OMDM-1 and OMDM-2, K(i) 2.4 and 3.0 micro M, respectively) being 6- to 7-fold more potent than the arachidonoyl analogues (OMDM-3 and OMDM-4). .
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In VitroOMDM-1 shows poor affinity for either CB1 (Ki=12.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively; OMDM-1 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50≥10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM).
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In Vivo——
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Synonyms(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number616884-62-9
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Formula Weight431.661
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Molecular FormulaC27H45NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CO)Cc1ccc(O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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N-Acetyl-L-alanine
N-Acetyl-L-alanine is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit Myelin basic protein GTP-binding nuclear protein Ran Tropomyosin alpha 4 chain HIV-1 Rev binding protein 2 Xaa-Pro dipeptidase Thymosin beta-10 Actin-like protein 3 Alanine aminotransferase Serine/threonine protein phosphatase PP1-beta catalytic subunit 10 kDa heat shock protein (mitochondrial) Calmodulin and Beta-1-syntrophin.
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6-Methylnicotinamide
6-Methylnicotinamide is a derivative of nicotinamide, an endogenous metabolite. 6-Methylnicotinamide is used to make co-crystals/salts.
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Cardiolipin (Heart, ...
Cardiolipin (Heart, Bovine) sodium is a phospholipid found in mitochondria and is involved in mitochondrial structure and function.Cardiolipin (Heart, Bovine) sodium is used in the study of neurological, cardiovascular, and metabolic diseases.
