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KIN101
CAS No. 610753-87-2
KIN101( 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene )
Catalog No. M26270 CAS No. 610753-87-2
KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 51 | In Stock |
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| 50MG | 84 | In Stock |
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| 100MG | 126 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKIN101
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NoteResearch use only, not for human use.
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Brief DescriptionKIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
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DescriptionKIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.(In Vitro):KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.
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In VitroKIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV). Western Blot Analysis Cell Line:MRC5 cells Concentration:10 μM Incubation Time:24 hours Result:Caused a significant decrease in the NP protein abundance. RT-PCR Cell Line:Huh7 cells Concentration:10 μM Incubation Time:18 hours Result:Showed a >1 log decrease in HCV RNA levels.
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In Vivo——
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Synonyms3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorNMDA
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Research Area——
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Indication——
Chemical Information
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CAS Number610753-87-2
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Formula Weight395.22
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Molecular FormulaC16H11BrO5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (105.43 mM)
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SMILESCS(=O)(=O)Oc1ccc2c(c1)occ(-c1ccc(Br)cc1)c2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275
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