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GSK2983559 free acid
CAS No. 1579965-12-0
GSK2983559 free acid( —— )
Catalog No. M26238 CAS No. 1579965-12-0
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 75 | In Stock |
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| 10MG | 116 | In Stock |
|
| 25MG | 207 | In Stock |
|
| 50MG | 297 | In Stock |
|
| 100MG | 434 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK2983559 free acid
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2).
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DescriptionGSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammatory bowel disease explant samples.
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In VitroGSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. Cell Viability Assay Cell Line:THP-1 cells Concentration:1-1024 nM Incubation Time:2 hours Result:Inhibited IL-8 production with an IC50 of 1.34 nM.
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In VivoGSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse. Animal Model:C57BL/6 mice (female) injected with MDP (100 μg) Dosage:3 and 10 mg/kg Administration:Oral gavage; 3 and 10 mg/kg; once Result:Suppressed serum IL-6 levels in a dose-dependent manner.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorleucyl-tRNA synthetase| Ras-related GTP-binding protein D (RagD)
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Research Area——
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Indication——
Chemical Information
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CAS Number1579965-12-0
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Formula Weight538.53
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Molecular FormulaC21H23N4O7PS2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (9.28 mM)
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SMILESCC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCOP(O)(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jong Hyun Kim, et al. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun. 2017 Sep 29;8(1):732.
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