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GNE-1858
CAS No. 2680616-96-8
GNE-1858( —— )
Catalog No. M26231 CAS No. 2680616-96-8
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 377 | In Stock |
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| 5MG | 353 | In Stock |
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| 10MG | 528 | In Stock |
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| 25MG | 851 | In Stock |
|
| 50MG | 1135 | In Stock |
|
| 100MG | 1535 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 3060 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-1858
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
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DescriptionGNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).(In Vitro):HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase.
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In VitroHematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor5-HT6
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Research Area——
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Indication——
Chemical Information
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CAS Number2680616-96-8
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Formula Weight428.492
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Molecular FormulaC21H26F2N8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (46.68 mM)
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SMILESCC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tse S, Leung L, Raje S, Seymour M, Shishikura Y, Obach RS. Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry. Drug Metab Dispos. 2014 Dec;42(12):2023-32.
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