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DPBQ

CAS No. 7029-89-2

DPBQ( 2,3-Diphenylbenzo[g]quinoxaline-5,10-dione | ZINC1620467 )

Catalog No. M26174 CAS No. 7029-89-2

DPBQ is a factor that activates p53.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DPBQ
  • Note
    Research use only, not for human use.
  • Brief Description
    DPBQ is a factor that activates p53.
  • Description
    DPBQ is a factor that activates p53.(In Vitro):DPBQ induces apoptosis and death and selectively affects 4N cells.DPBQ can specifically induce the expression and phosphorylation of p53.Deletion of TP53 can restore the proliferation of tetraploid cells in the presence of DPBQ.
  • In Vitro
    DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ.
  • In Vivo
    ——
  • Synonyms
    2,3-Diphenylbenzo[g]quinoxaline-5,10-dione | ZINC1620467
  • Pathway
    Apoptosis
  • Target
    p53
  • Recptor
    5-HT1| Dopamine Receptor| GABA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7029-89-2
  • Formula Weight
    362.38
  • Molecular Formula
    C24H14N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2.94 mg/mL (8.11 mM)
  • SMILES
    O=C1c2ccccc2C(=O)c2nc(-c3ccccc3)c(nc12)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.David B. Fick, et al. Tetrahydroindolone and purine derivatives linked to arylpiperazines. US 6770638 B2
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