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Pifithrin-α, p-Nitro, Cyclic
CAS No. 60477-38-5
Pifithrin-α, p-Nitro, Cyclic( PFN-α )
Catalog No. M24603 CAS No. 60477-38-5
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 398 | In Stock |
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| 100MG | 594 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePifithrin-α, p-Nitro, Cyclic
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NoteResearch use only, not for human use.
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Brief DescriptionPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
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DescriptionPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
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In VitroPifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.
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In VivoIntraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions).
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SynonymsPFN-α
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PathwayApoptosis
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Targetp53
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RecptorP53
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Research Area——
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Indication——
Chemical Information
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CAS Number60477-38-5
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Formula Weight299.35
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Molecular FormulaC15H13N3O2S
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Purity>98% (HPLC)
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SolubilityDMSO:5 mg/mL (16.70 mM; Need ultrasonic);DMF:12.5 mg/mL (41.76 mM; Need ultrasonic)
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SMILESC1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52.
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