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DHODH-IN-13
CAS No. 1364791-86-5
DHODH-IN-13( —— )
Catalog No. M26154 CAS No. 1364791-86-5
DHODH-IN-13 is the hydroxyfuran analogue of A771726.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 107 | In Stock |
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| 5MG | 119 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDHODH-IN-13
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NoteResearch use only, not for human use.
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Brief DescriptionDHODH-IN-13 is the hydroxyfuran analogue of A771726.
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DescriptionDHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
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In VitroDHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorE3 Ligase Ligand-Linker Conjugate
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Research Area——
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Indication——
Chemical Information
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CAS Number1364791-86-5
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Formula Weight273.171
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Molecular FormulaC10H6F3N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
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hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.
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DHODH-IN-11
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).
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DHODH-IN-16
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).
