D-Kynurenine

Research use only, not for human use.

D-Kynurenine is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme.

D-Kynurenine is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.(In Vitro):D-Kynurenine (10-100 μM) induces DER-enhancement and positively regulates the transfer of 95D cells, which is attenuated after siRNAAhr treatment in VIM and E-cadherin. D-Kynurenine (10 and 40 μM) significantly increases VIM expression and induces CYP1A1 upregulation. D-Kynurenine (10 μM) significantly attenuates the level of E-cadherin.

D-kynurenine (10, 40, 60, and 100 μM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 μM). 10 μM D-kynurenine markedly attenuates E-cadherin level. 10 μM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 μM D-kynurenine-induced up-regulation of CYP1A1, 10 μM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 μM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.

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(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid | ZINC901103

Cell Cycle/DNA Damage

GPR

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13441-51-5

208.217

C10H12N2O3

>98% (HPLC)

In Vitro:?H2O : 5 mg/mL (24.01 mM)

N[C@H](CC(=O)c1ccccc1N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years