Calmidazolium chloride

Research use only, not for human use.

Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM).

Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.(In Vitro):Calmidazolium chloride inhibits growth of mouse F9 ECCs (IC50 = 8.18 μM) and E14 ESCs (IC50 = 12.69 μM).

Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs. Cell Viability Assay Cell Line:Mouse F9 ECCs Concentration:3, 5, 7, 10 μM Incubation Time:30 minutes-24 hours Result:The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM.

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R 24571

Endocrinology/Hormones

CaMK

Autophagy| NF-κB| Reactive Oxygen Species

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57265-65-3

687.69

C31H23Cl7N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (145.41 mM)

[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years