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Lisaftoclax
CAS No. 2180923-05-9
Lisaftoclax( Bcl-2/Bcl-xl inhibitor 1 | APG-2575 )
Catalog No. M26069 CAS No. 2180923-05-9
Bcl-2/Bcl-xl inhibitor 1 is a dual Bcl-2 and Bcl-xl inhibitor (IC50s: 2 nM and 5.9 nM for Bcl-2 and Bcl-xl) with anti-tumor activity. It is extracted from patent WO2018027097A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 559 | In Stock |
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| 5MG | 393 | In Stock |
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| 10MG | 565 | In Stock |
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| 25MG | 838 | In Stock |
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| 50MG | 1097 | In Stock |
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| 100MG | 1488 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLisaftoclax
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NoteResearch use only, not for human use.
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Brief DescriptionBcl-2/Bcl-xl inhibitor 1 is a dual Bcl-2 and Bcl-xl inhibitor (IC50s: 2 nM and 5.9 nM for Bcl-2 and Bcl-xl) with anti-tumor activity. It is extracted from patent WO2018027097A1.
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DescriptionBcl-2/Bcl-xl inhibitor 1 is a dual Bcl-2 and Bcl-xl inhibitor (IC50s: 2 nM and 5.9 nM for Bcl-2 and Bcl-xl) with anti-tumor activity. It is extracted from patent WO2018027097A1.(In Vitro):Lisaftoclax shows IC50s of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4 11 cells and Bcl-xl dependent Molm 13 cells.
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In VitroLisaftoclax (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells.
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In Vivo——
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SynonymsBcl-2/Bcl-xl inhibitor 1 | APG-2575
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PathwayAngiogenesis
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TargetBcl-2
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RecptorE3 ligase ligand-linker conjugate
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Research Area——
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Indication——
Chemical Information
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CAS Number2180923-05-9
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Formula Weight882.43
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Molecular FormulaC45H48ClN7O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (113.32 mM)
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SMILES[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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