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NCGC00378430
CAS No. 920650-00-6
NCGC00378430( —— )
Catalog No. M24968 CAS No. 920650-00-6
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 264 | In Stock |
|
| 50MG | 372 | In Stock |
|
| 100MG | 518 | In Stock |
|
| 200MG | 705 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNCGC00378430
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NoteResearch use only, not for human use.
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Brief DescriptionNCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
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DescriptionNCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
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In VitroWestern Blot Analysis Cell Line:T47D cells Concentration:20 μM Incubation Time:3 days Result:Blocked TGF-β induced activation of p-Smad3, upregulation of FN1, and downregulation of E-CAD.
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In VivoAnimal Model:6-8 week old NSG mice with MCF7 tumor cellsDosage:25 mg/kg Administration:Local Injection to the site of tumor; every other day; from day 3 until the day 21 Result:Dramatically decreased distant metastatic burden compared to vehicle treatment.Had no growth inhibitory effect.Animal Model:Mice Dosage:20 mg/kg (Pharmacokinetic Analysis) Administration:IV Result:Had a T1/2α of 0.25 hours, a CL of 6.19 L/hr?kg, a Vss of 4.08 L/kg, a Cmax of 6703 ng/mL and an AUC of 3234 ng/mL?hr.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSIX1-EYA2
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Research Area——
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Indication——
Chemical Information
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CAS Number920650-00-6
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Formula Weight441.5
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Molecular FormulaC22H23N3O5S
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Purity>98% (HPLC)
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SolubilityDMSO:90 mg/mL?(203.85 mM;?Need ultrasonic)
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SMILESO=C(NC1=CC=C(OC)C(S(=O)(N2CCOCC2)=O)=C1)C3=CC=CC(N4C=CC=C4)=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hengbo Zhou, et al. Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res. 2020 Jun 15;80(12):2689-2702.
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