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MK-0159

CAS No. 2641484-61-7

MK-0159( —— )

Catalog No. M35606 CAS No. 2641484-61-7

MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-0159
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.
  • Description
    MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Cardiac I/R injury miceDosage:30 mg/kg Administration:p.o.Result:Reduced infarct size, and the combination of MK-0159 and NAD+ precursor significantly reduced the infarct size compared to MK-0159 alone.Increased whole heart NAD+ levels and decreased ADPR in the heart.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CD38
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2641484-61-7
  • Formula Weight
    400.495
  • Molecular Formula
    C20H24N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (249.69 mM; Ultrasonic )
  • SMILES
    COCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nc2[nH]ccc12)-c1cncs1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lagu B, et al. Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart. J Med Chem. 2022 Jun 28. ?
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