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Avoralstat
CAS No. 918407-35-9
Avoralstat( BCX4161 )
Catalog No. M24967 CAS No. 918407-35-9
Avoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 188 | In Stock |
|
| 50MG | 295 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAvoralstat
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NoteResearch use only, not for human use.
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Brief DescriptionAvoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.
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DescriptionAvoralstat is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. (In Vitro):C1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
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In VitroC1 inhibitor (C1INH) is the primary regulator of contact activation, both by inhibiting the conversion of prekallikrein to plasma kallikrein (PKK) by FXIIa, and by directly inhibiting PKK. PKK cleaves high molecular weight kininogen, releasing bradykinin, whose actions are responsible for the signs and symptoms of hereditary angioedema (HAE).
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In Vivo——
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SynonymsBCX4161
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PathwayOthers
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TargetOther Targets
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Recptorplasma kallikrein (PKK)
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Research Area——
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Indication——
Chemical Information
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CAS Number918407-35-9
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Formula Weight513.54
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Molecular FormulaC28H27N5O5
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (97.36 mM; Need ultrasonic)
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SMILESCOc(c(C=C)c1)cc(-c2ccc(C(NCC3CC3)=O)nc2C(O)=O)c1C(Nc(cc1)ccc1C(N)=N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5.
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