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AS1810722
CAS No. 909561-15-5
AS1810722( —— )
Catalog No. M24948 CAS No. 909561-15-5
AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 246 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 353 | In Stock |
|
| 25MG | 601 | In Stock |
|
| 50MG | 830 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAS1810722
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NoteResearch use only, not for human use.
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Brief DescriptionAS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.
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DescriptionAS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.
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In Vitro——
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In VivoAnimal Model:Female Balb/c mice asthmatic model by intraperitoneal injection of ovalbumin (OVA)-containing aluminum hydroxide gel Dosage:0.03-0.3 mg/kg Administration:Orally; 30 min before, and 24 and 48 h after OVA exposure Result:Suppressed eosinophil infiltration in the lung in a dose-dependent manner.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCYP3A4|STAT6
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Research Area——
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Indication——
Chemical Information
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CAS Number909561-15-5
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Formula Weight477.52
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Molecular FormulaC25H25F2N7O
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Purity>98% (HPLC)
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SolubilityDMSO : 62.5 mg/mL (130.89 mM; Need ultrasonic)
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SMILESO=C(N)CN1CCN(C2=CC=C(NC3=NC=C4C(N(CC5=CC(F)=CC(F)=C5)C=C4)=N3)C=C2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nagashima S , Hondo T , Nagata H , et al. Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors[J]. Bioorg Med Chem, 2009, 17(19):6926-6936.
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