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PIK-108
CAS No. 901398-68-3
PIK-108( PIK 108 | PIK108 )
Catalog No. M24934 CAS No. 901398-68-3
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 2MG | 49 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 150 | In Stock |
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| 25MG | 255 | In Stock |
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| 50MG | 360 | In Stock |
|
| 100MG | 498 | In Stock |
|
| 200MG | 684 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePIK-108
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NoteResearch use only, not for human use.
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Brief DescriptionPIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
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DescriptionPIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
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In VitroPIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt.Western Blot Analysis Cell Line:Glioma cell lines expressing wild-type PTEN Concentration:0.1, 0.5, 1, 4, and 10 μM Incubation Time:1 hour Result:Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines.
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In Vivo——
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SynonymsPIK 108 | PIK108
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα|PI3Kβ
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Research Area——
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Indication——
Chemical Information
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CAS Number901398-68-3
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Formula Weight364.44
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Molecular FormulaC22H24N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:45 mg/mL?(123.48 mM;?Need ultrasonic)
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SMILESO=C1C=C(N2CCOCC2)OC3=C(C(NC4=CC=CC=C4)C)C=C(C)C=C13
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Carry JC et al.. (2012) Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J. Med. Chem., 55 (10): 4788-805. [PMID:22524426]
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