Regorafénib N-oxyde (M2)( —— )

Catalog No. M24825 CAS No. 835621-11-9

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Regorafénib N-oxyde (M2)
Note

Research use only, not for human use.
Brief Description

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1.
Description

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

PDGFR
Recptor

VEGFR1|VEGFR2|VEGFR3|PDGFRβ|RET|Kit|Raf-1
Research Area

——
Indication

——

Chemical Information

CAS Number

835621-11-9
Formula Weight

498.81
Molecular Formula

C21H15ClF4N4O4
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

CNC(=O)C1=[N+](C=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F)[O-]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

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