Strophanthidin

Research use only, not for human use.

Strophanthidin can induce calcium overload in vivo.

Strophanthidin can induce calcium overload in vivo.

Strophanthidin (0~10 μM; 24 hours; MCF-7, A549, and HepG2 cells) is effective at suppressing the growth of cancer cells and has no toxicity in normal cells.Strophanthidin (0.5 to 500 μM; PBMCs) does not show significant cytotoxicity in PBMCs. Strophanthidin (2 μM; MCF-7 cells) can arrest cell cycle at the G2/M phase.Strophanthidin (MCF-7, A549, and HepG2 cells) is effective at suppressing the growth of cancer cells and has no toxicity in normal cells. Strophanthidin (MCF-7, A549, and HepG2 cells) inhibits the expression of checkpoint and cyclin-dependent kinases in three cancer cells compared to untreated controls. Strophanthidin can modulate the protein localization from the nucleus to the membrane as well as to the cytoplasm. Strophanthidin is a monosaccharide cardiac glycoside with one aglycone portion and without any sugar unit. Strophanthidin induces apoptosis by the attenuation of multiple biochemical signaling pathways and by arresting cell cycle at the G2/M phase through p53-dependent and p53-independent mechanisms. Cell Viability Assay Cell Line:MCF-7, A549, and HepG2 cells Concentration:0~10 μM Incubation Time:24 hours Result:Inhibited the proliferation in three different cancer cells.

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Strophanthidine

GPCR/G Protein

Calcium Channel

Calcium Channel

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66-28-4

404.5

C23H32O6

>98% (HPLC)

DMSO:10 mM

C[C@]12CC[C@H]3[C@H]([C@]1(CC[C@@H]2C4=CC(=O)OC4)O)CC[C@]5([C@@]3(CC[C@@H](C5)O)C=O)O

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(-20℃)

With Ice Pack

≥ 2 years