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NNK

CAS No. 64091-91-4

NNK( Nicotine-derived nitrosamine ketone )

Catalog No. M24655 CAS No. 64091-91-4

NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NNK
  • Note
    Research use only, not for human use.
  • Brief Description
    NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
  • Description
    NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
  • In Vitro
    NNK (100 pM; 0-60 min) stimulates activation of PKCα and MAPKs ERK1/2 that directly induce c-Myc phosphorylation.NNK (100 pM; 96 hours) enhances proliferation of cells expressing WT but not AA c-Myc mutant. Western Blot Analysis Cell Line:NCI-H82 cells Concentration:100 pM Incubation Time:0-60 min Result:Stimulated activation of PKCα and MAPKs ERK1/2 that directly induced c-Myc phosphorylation.Apoptosis Analysis Cell Line:H1299 lung cancer cells Concentration:100 pM Incubation Time:96 hours Result:Enhanced proliferation of cells expressing WT but not T58A/S62A c-Myc mutant.
  • In Vivo
    ——
  • Synonyms
    Nicotine-derived nitrosamine ketone
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    LOX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    64091-91-4
  • Formula Weight
    207.23
  • Molecular Formula
    C10H13N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    CN(CCCC(c1cnccc1)=O)N=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cheng G, Li J, Zheng M, Zhao Y, Zhou J, Li W. NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor. Int J Environ Res Public Health. 2014 Dec 23;12(1):64-82.
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