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JNJ-?10198409
CAS No. 627518-40-5
JNJ-?10198409( —— )
Catalog No. M24628 CAS No. 627518-40-5
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 5MG | 84 | In Stock |
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| 10MG | 124 | In Stock |
|
| 25MG | 210 | In Stock |
|
| 50MG | 303 | In Stock |
|
| 100MG | 433 | In Stock |
|
| 200MG | 607 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-?10198409
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM).
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DescriptionJNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.
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In VitroJNJ-10198409 has potent antiproliferative activity in six of eight human tumor cell lines (IC50<0.033 μM) and is a potent inhibitor of the c-Abl kinase (IC50=22 nM).
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDGFR
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RecptorPDGFRβ|PDGFRα
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Research Area——
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Indication——
Chemical Information
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CAS Number627518-40-5
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Formula Weight325.34
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Molecular FormulaC18H16FN3O2
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL?(256.13 mM;?Need ultrasonic)
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SMILESCOC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.D'Andrea MR, et al. Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis. Mol Cancer Ther. 2005 Aug;4(8):1198-204.
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