Cart
sales@molnova.com
SU16f
CAS No. 251356-45-3
SU16f( SU 16F | 3-substituted indolin-2-one 16f | SU-16F )
Catalog No. M26828 CAS No. 251356-45-3
SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 94 | In Stock |
|
| 5MG | 84 | In Stock |
|
| 10MG | 123 | In Stock |
|
| 25MG | 203 | In Stock |
|
| 50MG | 296 | In Stock |
|
| 100MG | 427 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSU16f
-
NoteResearch use only, not for human use.
-
Brief DescriptionSU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).
-
DescriptionSU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.(In Vitro):SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM. SU16f pretreatment causes the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA .
-
In VitroSU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .Cell Proliferation Assay Cell Line:SGC-7901 cells in GC-MSC/SGC-7901 co-culture system Concentration:20 μM Incubation Time:8 hours Result:Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. Western Blot Analysis Cell Line:SGC-7901 cells Concentration:20 μM Incubation Time:8 hours Result:Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
-
In Vivo——
-
SynonymsSU 16F | 3-substituted indolin-2-one 16f | SU-16F
-
PathwayAngiogenesis
-
TargetPDGFR
-
RecptorMDM-2/p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number251356-45-3
-
Formula Weight386.451
-
Molecular FormulaC24H22N2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (129.39 mM)
-
SMILESCc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732.
molnova catalog
related products
-
TSU-68
TSU-68 (Orantinib, SU6668) is a small-molecule, ATP-competitiv inhibitor of angiogenic related RTKs KDR, PDGFRβ, FGFR1.
-
Flumatinib mesylate
Flumatinib mesylate is a selective inhibitor of c-Abl PDGFRβ and c-Kit effectively overcomes drug resistance of certain KIT mutants.
-
PDGFRα kinase inhibi...
PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ) with IC50 values of 132 nM and 6115 nM, respectively.
