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TLR1
CAS No. 566914-00-9
TLR1( —— )
Catalog No. M24556 CAS No. 566914-00-9
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 125 | In Stock |
|
| 5MG | 119 | In Stock |
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| 10MG | 181 | In Stock |
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| 25MG | 293 | In Stock |
|
| 50MG | 384 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 200MG | 703 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTLR1
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NoteResearch use only, not for human use.
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Brief DescriptionTLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
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DescriptionTLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
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In VitroTLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner.
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In VivoTLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number566914-00-9
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Formula Weight302.41
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Molecular FormulaC18H26N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCC(C)[C@@H](C(=O)N1CCCC1)NC(=O)CCC2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6.
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