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Cytochalasin H

CAS No. 53760-19-3

Cytochalasin H( (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate )

Catalog No. M24524 CAS No. 53760-19-3

Cytochalasin H is a potent inhibitor of actin incorporation into filaments.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 415 In Stock
2MG 138 In Stock
5MG 226 In Stock
10MG 340 In Stock
25MG 554 In Stock
50MG 719 In Stock
100MG 986 In Stock
200MG 1330 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Cytochalasin H
  • Note
    Research use only, not for human use.
  • Brief Description
    Cytochalasin H is a potent inhibitor of actin incorporation into filaments.
  • Description
    Cytochalasin H is a potent inhibitor of actin incorporation into filaments.
  • In Vitro
    Apoptosis AnalysisCell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Induced apoptosis in a dose-dependent manner in the A549 cells.Cell Cycle Analysis Cell Line:A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Arrested cell cycle at the G2/M phase and sub-G1 peaks.Western Blot Analysis Cell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.
  • In Vivo
    Animal Model:male Balb/cnu/nu mice with A549 xenograftDosage:2.5 mg/kg Administration:intraperitoneal injection; 3 injections/week,for 80 days Result:Attenuated tumor growth in vivo.
  • Synonyms
    (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ET-1|MMP2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53760-19-3
  • Formula Weight
    493.63
  • Molecular Formula
    C30H39NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@H]([C@@H]([C@H](Cc1ccccc1)N1)[C@@]([C@H]([C@@H]2O)/C=C/C[C@H](C)C[C@](C)(/C=C3)O)([C@@H]3OC(C)=O)C1=O)C2=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ma Y , Xiu Z , Zhou Z , et al. Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells[J]. Journal of Cancer, 2019, 10(9).
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