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DC_AC50

CAS No. 497061-48-0

DC_AC50( —— )

Catalog No. M24456 CAS No. 497061-48-0

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DC_AC50
  • Note
    Research use only, not for human use.
  • Brief Description
    DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones).
  • Description
    DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.
  • In Vitro
    Cell Viability Assay Cell Line:Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells.Concentration:0-10 μM.Incubation Time:72 h.Result:Dose-dependently decreased viability of OSA cells.Apoptosis AnalysisCell Line:Abrams and HOS cells.Concentration:1, 3 and 10 μM (10 μM Carboplatin).Incubation Time:24 h.Result:Potentiated carboplatin-induced apoptosis.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Atox1|CCS|Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    497061-48-0
  • Formula Weight
    424.26
  • Molecular Formula
    C17H12BrF2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    NC1=C(SC2=C1C=C3CCCC3=N2)C(NC4=C(Br)C=C(C=C4F)F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18(4):559-569.
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