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DC_AC50
CAS No. 497061-48-0
DC_AC50( —— )
Catalog No. M24456 CAS No. 497061-48-0
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 100 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 290 | In Stock |
|
| 100MG | 435 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDC_AC50
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NoteResearch use only, not for human use.
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Brief DescriptionDC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones).
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DescriptionDC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.
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In VitroCell Viability Assay Cell Line:Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells.Concentration:0-10 μM.Incubation Time:72 h.Result:Dose-dependently decreased viability of OSA cells.Apoptosis AnalysisCell Line:Abrams and HOS cells.Concentration:1, 3 and 10 μM (10 μM Carboplatin).Incubation Time:24 h.Result:Potentiated carboplatin-induced apoptosis.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorAtox1|CCS|Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number497061-48-0
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Formula Weight424.26
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Molecular FormulaC17H12BrF2N3OS
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESNC1=C(SC2=C1C=C3CCCC3=N2)C(NC4=C(Br)C=C(C=C4F)F)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18(4):559-569.
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