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Eact

CAS No. 461000-66-8

Eact( —— )

Catalog No. M24413 CAS No. 461000-66-8

Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 75 In Stock
2MG 41 In Stock
5MG 68 In Stock
10MG 122 In Stock
25MG 254 In Stock
50MG 420 In Stock
100MG 618 In Stock
200MG 881 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Eact
  • Note
    Research use only, not for human use.
  • Brief Description
    Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
  • Description
    Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    TMEM16A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    461000-66-8
  • Formula Weight
    428.5
  • Molecular Formula
    C22H24N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (116.69 mM; Need ultrasonic)
  • SMILES
    COCCN(C1=NC(=CS1)C2=CC=CC=C2)C(=O)C3=CC(=C(C(=C3)OC)OC)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu S, et al. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18.
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