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Aurintricarboxylic acid
CAS No. 4431-00-9
Aurintricarboxylic acid( ATA | NSC-4056 | NSC 4056 | NSC4056 )
Catalog No. M24401 CAS No. 4431-00-9
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 39 | In Stock |
|
| 200MG | 55 | In Stock |
|
| 500MG | 87 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAurintricarboxylic acid
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NoteResearch use only, not for human use.
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Brief DescriptionAurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases.
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DescriptionAurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
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In VitroWestern Blot Analysis Cell Line:T98G, A172, GBM44 glioma cells Concentration:10 μM Incubation Time:0.5 hour, 1 hour, 2 hours Result:Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines.
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In Vivo——
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SynonymsATA | NSC-4056 | NSC 4056 | NSC4056
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|MicroRNA|rP2X1|rP2X3|Topoisomerase II
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Research Area——
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Indication——
Chemical Information
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CAS Number4431-00-9
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Formula Weight422.35
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Molecular FormulaC22H14O9
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (295.97 mM; Need ultrasonic)
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SMILESOC(c(cc(cc1)C(c(cc2)cc(C(O)=O)c2O)=C(C=C2)C=C(C(O)=O)C2=O)c1O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Liu T T , Yang T , Gao M N , et al. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations[J]. Acta Pharmacologica Sinica, 2019.
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