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API-1
CAS No. 36707-00-3
API-1( NSC177223 )
Catalog No. M24326 CAS No. 36707-00-3
API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 128 | In Stock |
|
| 5MG | 121 | In Stock |
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| 10MG | 207 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 551 | In Stock |
|
| 100MG | 770 | In Stock |
|
| 200MG | 1014 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAPI-1
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NoteResearch use only, not for human use.
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Brief DescriptionAPI-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
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DescriptionAPI-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
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In Vitro——
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In Vivo——
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SynonymsNSC177223
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number36707-00-3
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Formula Weight337.29
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Molecular FormulaC13H15N5O6
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC1=C(C(=O)C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ren H , Koo J , Guan B , et al. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis[J]. Molecular Cancer, 2013, 12(1):146-146.
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