Onjisaponin B
CAS No. 35906-36-6
Onjisaponin B( —— )
Catalog No. M24315 CAS No. 35906-36-6
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.
Purity : >98% (HPLC)
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Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 238 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 158 | In Stock |
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| 25MG | 267 | In Stock |
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| 50MG | 384 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameOnjisaponin B
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NoteResearch use only, not for human use.
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Brief DescriptionOnjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.
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DescriptionOnjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK|Autophagy|mTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number35906-36-6
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Formula Weight1573.69
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Molecular FormulaC75H112O35
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (63.55 mM)
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SMILESOC[C@](C1=CC[C@]2([H])[C@]3(C[C@H](O)[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)C)(CC[C@]6(C(O[C@H](O[C@H](C)[C@H](OC(/C=C/C7=CC=C(OC)C=C7)=O)[C@@H]8O[C@@](O[C@@H](C)[C@H](O)[C@H]9O)([H])[C@@H]9O)[C@@H]8O[C@@](O[C@@H](C)[C@H](O[C@@](OC[C@@H](O[C@]([C@@H]([C@@H](O)[C@H]%10O)O)([H])O[C@@H]%10CO)[C@@H]%11O)([H])[C@@H]%11O)[C@H]%12O)([H])[C@@H]%12O)=O)[C@@]1([H])CC(C)(C)CC6)[C@@]2(CC[C@@]3([H])[C@]4(C)C(O)=O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α±-synuclein and huntingtin in PC-12 cells.Int J Mol Sci. 2013 Nov 15;14(11):22618-41.
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