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PF-9363
CAS No. 2569009-58-9
PF-9363( CTX-3648 )
Catalog No. M24156 CAS No. 2569009-58-9
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | In Stock |
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| 10MG | 237 | In Stock |
|
| 25MG | 375 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 696 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-9363
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NoteResearch use only, not for human use.
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Brief DescriptionPF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
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DescriptionPF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
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In VitroPF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker.PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. Western Blot Analysis Cell Line:ZR75-1, T47D and MCF7 cells Concentration:0~1 μM Incubation Time:1 day Result:Down-regulated the expression of H3K23Ac biomarker.
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In VivoPF-9363 shows strong anti-tumor activity in patient-derived xenograft models.
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SynonymsCTX-3648
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorKAT6A/KAT6B
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Research Area——
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Indication——
Chemical Information
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CAS Number2569009-58-9
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Formula Weight444.46
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Molecular FormulaC20H20N4O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (112.50 mM)
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SMILESO=S(C1=C(OC)C=CC=C1OC)(NC2=NOC3=C2C(OC)=CC(CN4N=CC=C4)=C3)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation
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