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Home - Products - Chromatin/Epigenetic - Histone Demethylase - D-alpha-Hydroxyglutaric acid disodium salt

D-alpha-Hydroxyglutaric acid disodium salt

CAS No. 103404-90-6

D-alpha-Hydroxyglutaric acid disodium salt( D-2-HG | D-2-hydroxyglutarate )

Catalog No. M10168 CAS No. 103404-90-6

A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 29 In Stock
10MG 45 In Stock
25MG 64 In Stock
50MG 104 In Stock
100MG 183 In Stock
200MG 272 In Stock
500MG 456 In Stock
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Biological Information

  • Product Name
    D-alpha-Hydroxyglutaric acid disodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
  • Description
    A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    D-2-HG | D-2-hydroxyglutarate
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    α-KG
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    103404-90-6
  • Formula Weight
    192.08
  • Molecular Formula
    C5H6Na2O5
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 32 mg/mL
  • SMILES
    [O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
  • Chemical Name
    Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30. 2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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