RN-1 dihydrochloride

Research use only, not for human use.

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).(In Vitro):RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively.(In Vivo):In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9.

——

Animal Model:Sickle cell disease (SCD) miceDosage:3 mg/kg or 10 mg/kg Administration:i.p.; daily; for 2 or 4 consecutive weeks Result:Effectively induced HbF levels in red blood cells and reduced disease pathology in SCD mice.

——

Chromatin/Epigenetic

Histone Demethylase

——

——

——

1781835-13-9

452.42

C23H31Cl2N3O2

>98% (HPLC)

In Vitro:?H2O : 20 mg/mL (44.21 mM)

Cl.Cl.CN1CCN(CC1)C(=O)CNC1CC1c1ccc(OCc2ccccc2)cc1

——

(-20℃)

With Ice Pack

≥ 2 years