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EMAC10101d

CAS No. 2561476-24-0

EMAC10101d( —— )

Catalog No. M24151 CAS No. 2561476-24-0

compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 30 In Stock
5MG 29 In Stock
10MG 44 In Stock
25MG 89 In Stock
50MG 138 In Stock
100MG 207 In Stock
200MG 306 In Stock
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Biological Information

  • Product Name
    EMAC10101d
  • Note
    Research use only, not for human use.
  • Brief Description
    compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
  • Description
    compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
  • In Vitro
    EMAC10101d exhibits Ki values of 9627.4 nM, 8.1 nM, 224.6 nM and 154.9 nM for hCA Ⅰ, hCA II, hCAⅨand hCA Ⅻ, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Carbonic Anhydrase
  • Recptor
    hCAII
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2561476-24-0
  • Formula Weight
    428.36
  • Molecular Formula
    C17H15Cl2N3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    ClC1=CC(Cl)=C(C(N/2CC)=CSC2=N\C3=CC=C(S(=O)(N)=O)C=C3)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Meleddu R , Distinto S , Cottiglia F , et al. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII[J]. ACS Medicinal Chemistry Letters, 2020.
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