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EMAC10101d
CAS No. 2561476-24-0
EMAC10101d( —— )
Catalog No. M24151 CAS No. 2561476-24-0
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
|
| 5MG | 72 | In Stock |
|
| 10MG | 125 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 403 | In Stock |
|
| 100MG | 592 | In Stock |
|
| 500MG | 1242 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEMAC10101d
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NoteResearch use only, not for human use.
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Brief Descriptioncompound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
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Descriptioncompound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
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In VitroEMAC10101d exhibits Ki values of 9627.4 nM, 8.1 nM, 224.6 nM and 154.9 nM for hCA Ⅰ, hCA II, hCAⅨand hCA Ⅻ, respectively.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetCarbonic Anhydrase
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RecptorhCAII
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Research Area——
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Indication——
Chemical Information
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CAS Number2561476-24-0
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Formula Weight428.36
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Molecular FormulaC17H15Cl2N3O2S2
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESClC1=CC(Cl)=C(C(N/2CC)=CSC2=N\C3=CC=C(S(=O)(N)=O)C=C3)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Meleddu R , Distinto S , Cottiglia F , et al. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII[J]. ACS Medicinal Chemistry Letters, 2020.
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