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Solabegron
CAS No. 252920-94-8
Solabegron( GW 427353 )
Catalog No. M24143 CAS No. 252920-94-8
Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
|
| 5MG | 159 | In Stock |
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| 10MG | 259 | In Stock |
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| 25MG | 472 | In Stock |
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| 50MG | 625 | In Stock |
|
| 100MG | 830 | In Stock |
|
| 200MG | 1097 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSolabegron
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NoteResearch use only, not for human use.
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Brief DescriptionSolabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
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DescriptionSolabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome. (In Vivo):Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity.
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In Vitro——
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In VivoSolabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity. Animal Model:Adult female beagle dogs (6-10 kg).Dosage:1, 3 mg/kg.Administration:I.V. once.Result:Dosage of 3 mg/kg evoked an increase in micturition volume threshold.
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SynonymsGW 427353
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PathwayApoptosis
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TargetAdenosine Receptor
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Recptorβ3-adrenergic receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number252920-94-8
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Formula Weight410.89
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Molecular FormulaC23H23ClN2O3
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (608.44 mM; Need ultrasonic)
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SMILESC1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9.
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