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Nampt-IN-5
CAS No. 2380013-17-0
Nampt-IN-5( —— )
Catalog No. M24096 CAS No. 2380013-17-0
Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 164 | In Stock |
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| 5MG | 150 | In Stock |
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| 10MG | 264 | In Stock |
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| 25MG | 420 | In Stock |
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| 50MG | 551 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNampt-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionNampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
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DescriptionNampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
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In VitroNampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively .Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min?mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.
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In VivoNampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle.Nampt-IN-5 (10 mg/kg; p.o.) exhibits T1/2 (2.1 h), Cmax (29112 nM), and AUC (61984 nM?h) in mice.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetNAMPT
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RecptorNampt
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Research Area——
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Indication——
Chemical Information
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CAS Number2380013-17-0
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Formula Weight427.5
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Molecular FormulaC25H25N5O2
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Purity>98% (HPLC)
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SolubilityDMSO:48mg/ml(112.28mM;Need ultrasonic)
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SMILESO=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529.
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