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Nampt-IN-5

CAS No. 2380013-17-0

Nampt-IN-5( —— )

Catalog No. M24096 CAS No. 2380013-17-0

Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nampt-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
  • Description
    Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
  • In Vitro
    Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively .Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min?mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.
  • In Vivo
    Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle.Nampt-IN-5 (10 mg/kg; p.o.) exhibits T1/2 (2.1 h), Cmax (29112 nM), and AUC (61984 nM?h) in mice.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    NAMPT
  • Recptor
    Nampt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2380013-17-0
  • Formula Weight
    427.5
  • Molecular Formula
    C25H25N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48mg/ml(112.28mM;Need ultrasonic)
  • SMILES
    O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529.
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