G150

Research use only, not for human use.

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).

G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages.?G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages.?G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells.RT-PCR Cell Line:Human THP1 cells and primary human macrophages Concentration:0.1-100 μM Incubation Time:1 hour Result:Dose-dependently inhibited IFNB1 and interferon-stimulated genes monitoring CXCL10 expression with IC50s of 1.96 and 7.57 μM respectively in human THP1 cells, and inhibited IFNB1 and CXCL10 expression with IC50s of 0.62 and 0.87 μM respectively in primary human macrophages.RT-PC RCell Line:Human THP1 cells and primary human macrophages Concentration:5 and 10 μM Incubation Time:1 hour Result:Inhibited dsDNA sensing with a concentration of 10 μM in THP1 cells and with a concentration of 5 μM in primary human macrophages.RT-PCR Cell Line:THP1-Dual cells Concentration:0.1-100 μM Incubation Time:1 hour Result:Inhibited SEAP activity and luciferase activity with IC50s of 0.90 and 1.79 μM respectively in THP1-Dual cells.

——

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

dsDNA/cGAS|h-cGAS

——

——

2369751-30-2

391.25

C18H16Cl2N4O2

>98% (HPLC)

DMSO:120 mg/mL (306.71 mM; Need ultrasonic)

Nc(cc1)ncc1-c(c1c2[nH]c(CC3)c1CN3C(CO)=O)cc(Cl)c2Cl

——

(-20℃)

With Ice Pack

≥ 2 years