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TRPV4 agonist-1 free base
CAS No. 2314467-59-7
TRPV4 agonist-1 free base( OUN67600 )
Catalog No. M24056 CAS No. 2314467-59-7
TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 89 | In Stock |
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| 25MG | 179 | In Stock |
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| 50MG | 277 | In Stock |
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| 100MG | 384 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTRPV4 agonist-1 free base
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NoteResearch use only, not for human use.
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Brief DescriptionTRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
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DescriptionTRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
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In VitroTRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
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In Vivo——
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SynonymsOUN67600
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPV4
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Research Area——
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Indication——
Chemical Information
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CAS Number2314467-59-7
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Formula Weight448.46
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Molecular FormulaC25H22F2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL?(185.81 mM;?Need ultrasonic)
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SMILESCN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
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