ICILIN( AG 3-5 )

Catalog No. M14271 CAS No. 36945-98-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

ICILIN
Note

Research use only, not for human use.
Brief Description

Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
Description

Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
In Vitro

Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+?dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization. Cell Viability Assay Cell Line:TRPM8-expressing oocytes or HEK293 cells Concentration:10 μM Incubation Time:3 minutes for TRPM8-expressing oocytes; 1 minute for HEK293 cells Result:Activated membrane currents with variable delay of onset in voltage-clamped TRPM8-expressing oocytes or HEK293 cells.
In Vivo

Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin?(3 mg/kg; s.c.) induces“Wet dog shake” in mice. Animal Model:The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g).Dosage:3 mg/kg Administration:Injected s.c.Result:Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.?
Synonyms

AG 3-5
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPM8
Research Area

Cancer
Indication

——

CAS Number

36945-98-9
Formula Weight

311.29
Molecular Formula

C16H13N3O4
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C1NC(C2=CC=CC([N+]([O-])=O)=C2)=CCN1C3=CC=CC=C3O
Chemical Name

3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone

1.Lee S, et al. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10.

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