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VU6012962

CAS No. 2313526-86-0

VU6012962( —— )

Catalog No. M24054 CAS No. 2313526-86-0

VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 75 In Stock
2MG 42 In Stock
5MG 68 In Stock
10MG 122 In Stock
25MG 237 In Stock
50MG 417 In Stock
100MG 612 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    VU6012962
  • Note
    Research use only, not for human use.
  • Brief Description
    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
  • Description
    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
  • In Vitro
    VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.
  • In Vivo
    VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice. Animal Model:C57Bl/6J male mice (8 weeks old)Dosage:1, 3, and 10 mg/kg Administration:I.p. injections; 60 minutes prior to testing Result:Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGlu7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2313526-86-0
  • Formula Weight
    448.4
  • Molecular Formula
    C21H19F3N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (278.77 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.
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