Bemnifosbuvir hemisulfate

Research use only, not for human use.

Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.

Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.

Bemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively.In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo.

AT-527

Others

Other Targets

SARS-CoV-2

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2241337-84-6

1261.15

C48H68F2N14O18P2S

>98% (HPLC)

DMSO : 170 mg/mL?(269.60mM;?Need ultrasonic)

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(-20℃)

With Ice Pack

≥ 2 years