Cart
sales@molnova.com
SU0268
CAS No. 2210228-45-6
SU0268( —— )
Catalog No. M23997 CAS No. 2210228-45-6
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 5MG | 92 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 306 | In Stock |
|
| 50MG | 477 | In Stock |
|
| 100MG | 695 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSU0268
-
NoteResearch use only, not for human use.
-
Brief DescriptionSU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
-
DescriptionSU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
-
In VitroCell Viability Assay Cell Line:A549 shGFP and shMTH1 (2000 cells per well).Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.Incubation Time:24 or 48 h.Result:The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.
-
In VivoAnimal Model:Anesthetized C57BL/6N mice.Dosage:10 mg/kg.Administration:Intranasally treated.Result:Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor8-oxoguanine DNA glycosylase 1 (OGG1)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2210228-45-6
-
Formula Weight475.56
-
Molecular FormulaC26H25N3O4S
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (210.28 mM; Need ultrasonic)
-
SMILESO=C(C1=CC(C2=CC=C(S(=O)(NC3=CC4=C(C=C3)CCCN4C(C5CC5)=O)=O)C=C2)=CC=C1)N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848.
molnova catalog
related products
-
Ciproquazone
Ciproquazone has analgesic activity and is used to treat spondylitis.
-
7β-Hydroxyganodereni...
12β-Acetoxy-7β-hydroxy-3,11,15,23-tetraoxo-5a-lanosta-8,20-dien-26-oic acid, a lanostanoid triterpene that can be isolated from Ganoderma lingzhi, exhibits an IC50 of 80.8 μM in MCF-7 cells.
-
Cyclic MKEY
MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not been studied.
