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SU0268
CAS No. 2210228-45-6
SU0268( —— )
Catalog No. M23997 CAS No. 2210228-45-6
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 306 | In Stock |
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| 50MG | 477 | In Stock |
|
| 100MG | 695 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSU0268
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NoteResearch use only, not for human use.
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Brief DescriptionSU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
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DescriptionSU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
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In VitroCell Viability Assay Cell Line:A549 shGFP and shMTH1 (2000 cells per well).Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.Incubation Time:24 or 48 h.Result:The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.
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In VivoAnimal Model:Anesthetized C57BL/6N mice.Dosage:10 mg/kg.Administration:Intranasally treated.Result:Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor8-oxoguanine DNA glycosylase 1 (OGG1)
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Research Area——
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Indication——
Chemical Information
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CAS Number2210228-45-6
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Formula Weight475.56
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Molecular FormulaC26H25N3O4S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (210.28 mM; Need ultrasonic)
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SMILESO=C(C1=CC(C2=CC=C(S(=O)(NC3=CC4=C(C=C3)CCCN4C(C5CC5)=O)=O)C=C2)=CC=C1)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848.
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