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BAY-1797
CAS No. 2055602-83-8
BAY-1797( —— )
Catalog No. M23922 CAS No. 2055602-83-8
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | In Stock |
|
| 10MG | 132 | In Stock |
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| 25MG | 267 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 705 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY-1797
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects.
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DescriptionBAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels.
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In Vitro——
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In VivoAnimal Model:Female adult C57BL/6N mice (CFA inflammatory pain model)Dosage:12.5, 25, 50 mg/kg Administration:p.o.; once Result:Dose-dependently reduced PGE2 concentration in inflamed paw.Animal Model:Rat male Wistar Dosage:1 mg/kg Administration:i.v. (Pharmacokinetic Analysis)Result:The AUCnorm, Vss and t1/2 were 1.06 kg h/L, 3.67 L/kg and 2.64 hours, respectively.
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Synonyms——
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PathwayNeuroscience
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TargetP2 Receptor
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Recptorhuman P2X4|human P2X1|human P2X23|human P2X3|human P2X7
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Research Area——
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Indication——
Chemical Information
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CAS Number2055602-83-8
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Formula Weight416.88
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Molecular FormulaC20H17ClN2O4S
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (599.69 mM; Need ultrasonic)
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SMILESC1=CC=C(C=C1)CC(=O)NC2=CC(=C(C=C2)OC3=CC(=CC=C3)Cl)S(=O)(=O)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Werner S, et al. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem. 2019 Dec 26;62(24):11194-11217.
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