ICCB280

Research use only, not for human use.

ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.

ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.

ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM.ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells. Cell Viability Assay Cell Line:HL-60 cells Concentration:0.1, 0.5, 1, 5, 10, 50 μM Incubation Time:48 hours Result:Induced cell growth arrest, with an IC50 of 8.6 μM.Western Blot Analysis Cell Line:HL-60 cells Concentration:10 μM Incubation Time:2, 4, 6, 8 days Result:Upregulated the C/EBPα protein on day 4.

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Others

Other Targets

C/EBPα

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2041072-41-5

386.4

C23H18N2O4

>98% (HPLC)

DMSO:85mg/mL (219.98mM)

O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years