Cart
sales@molnova.com
Lanraplenib
CAS No. 1800046-95-0
Lanraplenib( GS-9876 )
Catalog No. M23810 CAS No. 1800046-95-0
Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 111 | In Stock |
|
| 2MG | 65 | In Stock |
|
| 5MG | 96 | In Stock |
|
| 10MG | 162 | In Stock |
|
| 25MG | 291 | In Stock |
|
| 50MG | 421 | In Stock |
|
| 100MG | 620 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLanraplenib
-
NoteResearch use only, not for human use.
-
Brief DescriptionLanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
-
DescriptionLanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
-
In Vitro——
-
In Vivo——
-
SynonymsGS-9876
-
PathwayAngiogenesis
-
TargetSyk
-
RecptorSYK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1800046-95-0
-
Formula Weight443.5
-
Molecular FormulaC23H25N9O
-
Purity>98% (HPLC)
-
SolubilityDMSO:41.67 mg/mL (93.96 mM; Need ultrasonic)
-
SMILESC1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Di Paolo J, et al. FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis.Annals of the Rheumatic Diseases 2016;75:443-444.
molnova catalog
related products
-
R788 disodium hexahy...
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM.
-
TAK-659 hydrochlorid...
TAK-659 hydrochloride (Mivavotinib, TAK659) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
-
RO9021
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
