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Lanraplenib
CAS No. 1800046-95-0
Lanraplenib( GS-9876 )
Catalog No. M23810 CAS No. 1800046-95-0
Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 111 | In Stock |
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| 2MG | 65 | In Stock |
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| 5MG | 96 | In Stock |
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| 10MG | 162 | In Stock |
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| 25MG | 291 | In Stock |
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| 50MG | 421 | In Stock |
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| 100MG | 620 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLanraplenib
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NoteResearch use only, not for human use.
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Brief DescriptionLanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
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DescriptionLanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
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In Vitro——
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In Vivo——
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SynonymsGS-9876
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PathwayAngiogenesis
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TargetSyk
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RecptorSYK
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Research Area——
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Indication——
Chemical Information
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CAS Number1800046-95-0
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Formula Weight443.5
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Molecular FormulaC23H25N9O
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Purity>98% (HPLC)
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SolubilityDMSO:41.67 mg/mL (93.96 mM; Need ultrasonic)
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SMILESC1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Di Paolo J, et al. FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis.Annals of the Rheumatic Diseases 2016;75:443-444.
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