ZYN57939( MTR-106 )

Catalog No. M23736 CAS No. 1639357-93-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ZYN57939
Note

Research use only, not for human use.
Brief Description

ZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.
Description

ZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.
In Vitro

Cell Viability Assay Cell Line:HR-deficient and PARPi-resistant cancer cells Concentration:0-100 μM Incubation Time:7 days Result:Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.Cell Cycle Analysis Cell Line:Capan-1 cells Concentration:0.1, 0.3, and 1 μM Incubation Time:24 hours Result:Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.Western Blot Analysis Cell Line:Capan-1 cells Concentration:1, 5, and 10 μM Incubation Time:24 hours Result:Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.
In Vivo

Animal Model:BRCA-deficient and PARPi-resistant xenografts in nude mice Dosage:10, 20, and 30 mg/kg Administration:oral administration; twice a week, for 29 days Result:Inhibited tumor growth in a dose-dependent manner.
Synonyms

MTR-106
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

RNA polymerase I
Research Area

——
Indication

——

CAS Number

1639357-93-9
Formula Weight

524.62
Molecular Formula

C29H28N6O2S
Purity

>98% (HPLC)
Solubility

DMSO:Insoluble;Water:Insoluble
SMILES

O=C1C(C(NCC2=NC=C(N=C2)C)=O)=C(SC3=CC=CC=C34)N4C5=NC(C6C[C@@](CN(C)C7)([H])[C@@]7([H])C6)=CC=C15
Chemical Name

——

1.Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers[J]. Investigational New Drugs, 2021:1-9.

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